Antisense Oligonucleotide Therapies for Neurodegenerative Diseases
نویسندگان
چکیده
منابع مشابه
Antisense oligonucleotide therapy for neurodegenerative disease.
Neurotoxicity from accumulation of misfolded/mutant proteins is thought to drive pathogenesis in neurodegenerative diseases. Since decreasing levels of proteins responsible for such accumulations is likely to ameliorate disease, a therapeutic strategy has been developed to downregulate almost any gene in the CNS. Modified antisense oligonucleotides, continuously infused intraventricularly, have...
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1Department of Biochemistry, Center for Oxidative Stress Research, Federal University of Rio Grande do Sul (UFRGS), 90035-003 Porto Alegre, RS, Brazil 2Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada L85 4K1 3Experimental & Translational Respiratory Group, University of Newcastle, Newsastle, NSW 2308, Australia 4Department of Biochemistry, Cente...
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ژورنال
عنوان ژورنال: Annual Review of Neuroscience
سال: 2019
ISSN: 0147-006X,1545-4126
DOI: 10.1146/annurev-neuro-070918-050501